6 edition of Probing of nucleic acids by metal ion complexes of small molecules found in the catalog.
Probing of nucleic acids by metal ion complexes of small molecules
Includes bibliographical references and index.
|Statement||edited by Astrid Sigel and Helmut Sigel.|
|Series||Metal ions in biological systems -- v. 33|
|Contributions||Sigel, Astrid., Sigel, Helmut.|
|The Physical Object|
|Pagination||xli, 678 p. :|
|Number of Pages||678|
Tris(phenanthroline) metal complexes bind to the double helix both by intercalation in the major groove and through hydrophobic association in the minor groove. 11b,40 Intercalation and minor groove-binding are, in fact, the two most common modes of noncovalent association of small molecules with nucleic acids. In addition, as with other small. Platinum and Biological Systems Metal Ions in Biological Systems, Volume Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules Edited by Astrid Sigel and Helmut Sigel, Marcel Dekker, New York, , pages, ISBN , U.S.$
Metal ions in biological systems. Published: () Probing of nucleic acids by metal ion complexes of small molecules / Published: () Metal ions and neurodegenerative disorders Published: () Metal ions and their complexes in medication / Published: (). Recommended Citation. Robert F. Pasternack and E. J. Gibbs. (). "Porphyrin And Metalloporphyrin Interactions With Nucleic Acids". Probing Of Nucleic Acids By Metal Ion Complexes Of Small Molecules.
to probe nucleic acid structure. The central transition metal ion provides both a rigid, substitutionally inert framework and an octahedral geometry for ligand coordination. The metal complexes can be constructed to define shapes, symmetries, and functionalities that complement those of the nucleic acid target. In addition, the rich. In this review, we summarize the recent advances in the use of pyrene-modified oligonucleotides as a platform for functional nucleic acid-based constructs. Pyrene is of special interest for the development of nucleic acid-based tools due to its unique fluorescent properties (sensitivity of fluorescence to the microenvironment, ability to form excimers and exciplexes, long fluorescence lifetime.
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Book Description Table of Contents Reviews Book Description "Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts.".
Author(s): Sigel,Astrid; Sigel,Helmut Title(s): Probing of nucleic acids by metal ion complexes of small molecules/ edited by Astrid Sigel and Helmut Sigel.
Country of Publication: United States Publisher: New York: Marcel Dekker, c Description: xli, p.: ill.
Abstract. Nucleic acids are responsible for the storage, transmission, and expression of genetic information in all living organisms.
These macromolecules tend to behave as salts in solution since the negative charges of the polynucleotide phosphodiester backbone are usually neutralized by metal solute by: 3. Febru "Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts.".
Volume Probing Nucleic Acids by Metal Ion Complexes of Small Molecules Volume Mercury and Its Effects on Environment and Biology Volume Iron Transport and Storage in Microorganisms, Plants, and Animals Volume Interrelations between Free Radicals and Metal Ions in Life Processes Volume Manganese and Its Role in Biological.
Interactions of metal ions with nucleotides, nucleic acids, and their constituents A. Sigel and H. Sigel, Eds. Marcel Dekker Inc., New York.
xxxix + pp. 16 × cm. ISBN $ Metal Ions in Biological Systems. Volume Probing of nucleic acids by metal ion complexes of small molecules. Sigel, A. and Sigel, H. () Metal ions in Biological Systems, vol Probing of Nucleic acids by metal ion complexes of small molecules, Marcel Dekker, New York Google Scholar Ferguson, L.R.
and Denny, W.A. () The genetic toxicology of acridines, Mutation ReseachMetal Ions and the Thermodynamics of RNA Folding David P. Giedroc and Nicholas E. Grossoehme Efforts to understand, in physical terms, how Mg2+ ions specifically stabilize the folded states of complex RNA molecules relative to component RNA duplexes go back over 35 years with early studies of the binding of and stabilization by, Mg2+ ions to.
Functional nucleic acids. As some heavy metal ions can form complexes with certain nucleic acid bases and structures (Clever et al., ), functional nucleic acid (FNA) is recently developed for the fabrication of specific sensors for heavy metal ions (Li et al., a, Li et al.,Wang et al., ).
The nucleic acid has high. Summary: Focuses on the research area of probing nucleic acids - the carriers of the genetic code - by metal ion complexes of small molecules.
Fundamental Interactions with Nucleic Acids Metal ions and complexes associate with DNA and RNA in a variety of ways, as illustrated in Figure Both strong covalent interactions and weak nonco valent complexes are observed Each may yield a significant perturbation in the nucleic acid and/or may be exploited to obtain a site.
Probing of nucleic acids by metal ion complexes of small molecules (Metal ions in biological systems. Vol. 33) Get this from a library. Metal ions in biological systems.
Vol. 33, Probing of nucleic acids by metal ion complexes of small molecules. [Helmut Sigel; Astrid Sigel;]. Metal Ions in Biological Systems, Volume Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules EDITED BY ASTRID SIGEL AND HELMUT SIGEL, Marcel Dekker, New York,pages, ISBNU.S.$ Metal ions perform an important role in the structure and stability of the DNA double helix.
ions and metal complexes with nucleic acids [2 small molecules and metal ions, which can be useful for troscopy has been used extensively to probe metal ion. Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes.
The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and. This special issue on the "Metal complexes interactions with Nucleic acids and/or DNA" aims to provide an overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity.
Prof. Sotiris Hadjikakou Dr. Christina N. Banti Guest Editors. Nucleic acids are targets of metal-based therapeutic agents, the most well-known being the Pt II anticancer compounds.
7 RNA and DNA polymerases perform phosphoryl transfer chemistry catalyzed by Mg II and Zn II. 8,9 Several nucleases, enzymes that cleave nucleic acids, also use these ions.
Several X‐ray structures of Pt(II)‐nucleic acid complexes are known, especially concerning cis‐diamminedichloro platinium(II) (cisplatin) which is a well‐known anticancer agent. Contrary to Pt(II), which can adopt square‐planar and octahedral geometry, Pt(IV) adopts only an.
[PDF] Hybridization With Nucleic Acid Probes Part II: Probe Labeling and Hybridization Techniques. For example, two thymines and cytosines coordinate to Hg 2+ and Ag +, respectively, to form a M-DNA (metal ion DNA complex) duplex through the formation of metal .ion atmosphere that surrounds nucleic acids.
We have used a simple model DNA system to determine how the ion atmosphere modulates interactions between duplexes in the absence of spe-ciﬁc metal ion-binding sites and other complicated interactions. In .